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Larazotide acetate also known as AT-1001, is a tight junction regulator and reverses leaky junctions to their normally closed state.

Peptide H-GGVLVQPG-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-GGVLVQPG-OH include the following: Human zonulin, a potential modulator of intestinal tight junctions W Wang, S Uzzau , SE Goldblum - Journal of cell , 2000 - journals.biologists.comhttps://journals.biologists.com/jcs/article-abstract/113/24/4435/26351 Expression of Vibrio cholerae zonula occludens toxin and analysis of its subcellular localization S Uzzau , P Cappuccinelli , A Fasano - Microbial pathogenesis, 1999 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0882401099903121 Intestinal permeability and inflammatory features of juvenile age correlate with the eventual systemic autoimmunity in lupus-prone female SWRacaâ\x80\x94 NZB F1 (SNF1) mice RR Gudi, BM Johnson, MC Gaudreau , W Sun - , 2024 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/imm.13713 Targeting intestinal epithelial barrier function to prevent onset of arthritis N Tajik - 2021 - search.proquest.comhttps://search.proquest.com/openview/6844da37c50fba413123846b3b150c94/1?pq-origsite=gscholar&cbl=2026366&diss=y Multifaceted interactions of bacterial toxins with the gastrointestinal mucosa MR Popoff - Future Microbiology, 2011 - Future Medicinehttps://www.futuremedicine.com/doi/abs/10.2217/fmb.11.58 Investigating Markers of Intestinal Barrier Dysfunction in Gastrointestinal Diseases MA Ajamian - 2019 - scholar.archive.orghttps://scholar.archive.org/work/3ociy3ec5jcifaobsjaeqy37ua/access/wayback/https://au-east.erc.monash.edu.au/fpfiles/15469340/MAjamian_Thesis_12.06.2019.pdf Zonula occludens toxin acts as an adjuvant through different mucosal routes and induces protective immune responses M Marinaro, A Fasano , MT De Magistris - Infection and immunity, 2003 - Am Soc Microbiolhttps://journals.asm.org/doi/abs/10.1128/iai.71.4.1897-1902.2003 Zonula occludens toxin structure-function analysis: identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain M Di Pierro, R Lu, S Uzzau , W Wang - Journal of Biological , 2001 - ASBMBhttps://www.jbc.org/article/S0021-9258(19)67052-3/abstract Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems M Ajamian , D Steer, G Rosella, PR Gibson - PloS one, 2019 - journals.plos.orghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210728 Lack of relationship of AT1001 to zonulin and prehaptoglobin-2: clinical implications LM Sollid , F Koning - Gut, 2021 - gut.bmj.comhttps://gut.bmj.com/content/70/11/2211.abstract Widely used commercial ELISA does not detect precursor of haptoglobin2, but recognizes properdin as a potential second member of the zonulin family L Scheffler, A Crane, H Heyne , A Tönjes - Frontiers in , 2018 - frontiersin.orghttps://www.frontiersin.org/articles/10.3389/fendo.2018.00022/full Widely used commercial ELISA does not detect preHP-2, but recognizes properdin as a potential second member of the zonulin family L Scheffler, A Crane, H Heyne , A Tönjes, D Schleinitz - bioRxiv, 2017 - biorxiv.orghttps://www.biorxiv.org/content/10.1101/157578.abstract Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms J Visser, J Rozing, A Sapone - Annals of the New , 2009 - Wiley Online Libraryhttps://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.2009.04037.x Assessment of haptoglobin alleles in autism spectrum disorders FA Cupaioli, E Mosca , C Magri, M Gennarelli - Scientific Reports, 2020 - nature.comhttps://www.nature.com/articles/s41598-020-64679-w Colonic paracellular permeability and circulating zonulin-related proteins F Meira de-Faria , O Bednarska, M Ström - Scandinavian Journal , 2021 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/00365521.2021.1879247 Development of celiac disease; pathogenesis and strategies to control: a molecular approach D Gayathri, BS Rashmi - Journal of Nutrition & Food Sciences, 2014 - researchgate.nethttps://www.researchgate.net/profile/Gayathri-Devaraja/publication/278782683_Development_of_Celiac_Disease_Pathogenesis_and_Strategies_to_Control_A_Molecular_Approach/links/583d634408aeb3987e31073e/Development-of-Celiac-Disease-Pathogenesis-and-Strategies-to-Control-A-Molecular-Approach.pdf The intestinal zonula occludens toxin (ZOT) receptor recognises non-native ZOT conformers and localises to the intercellular contacts A Lee, N White, CF van der Walle - FEBS letters, 2003 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0014579303013486 Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall A Fasano - The American journal of pathology, 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S000294401061512X