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90614-48-5,抑二肽素A、Diprotin A、Ile-Pro-Ile,安徽专肽生物的产品

抑二肽素A、Diprotin A

An inhibitor of dipeptidyl aminopeptidase IV.

编号:138690

CAS号:90614-48-5

单字母:H2N-IPI-OH

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  • 编号:138690
    中文名称:抑二肽素A、Diprotin A
    英文名:Diprotin A
    CAS号:90614-48-5
    单字母:H2N-IPI-OH
    三字母:H2N

    N端氨基:N-terminal amino group。在肽或多肽链中含有游离a-氨基的氨基酸一端。在表示氨基酸序列时,通常将N端放在肽链的左边。

    -Ile

    L-异亮氨酸:isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子,是哺乳动物的必需氨基酸。符号:I,Ile。

    -Pro

    L-脯氨酸:proline。系统命名为吡咯烷-(2S)-羧酸。为亚氨基酸。是编码氨基酸。在肽链中有特殊作用,如易形成顺式的肽键等。符号:P,Pro。

    -Ile

    L-异亮氨酸:isoleucine。系统命名为(2S)-氨基-(3R)-甲基戊酸。是编码氨基酸。有两个手性碳原子,是哺乳动物的必需氨基酸。符号:I,Ile。

    -OH

    C端羧基:C-terminal carboxyl group。在肽或多肽链中含有游离羧基的氨基酸一端。在表示氨基酸序列时,通常将C端放在肽链的右边。

    氨基酸个数:3
    分子式:C17H31N3O4
    平均分子量:341.45
    精确分子量:341.23
    等电点(PI):-
    pH=7.0时的净电荷数:0.97
    平均亲水性:-1.8
    疏水性值:2.47
    外观与性状:白色粉末状固体
    消光系数:-
    来源:人工化学合成,仅限科学研究使用,不得用于人体。
    纯度:95%、98%
    盐体系:可选TFA、HAc、HCl或其它
    生成周期:2-3周
    储存条件:负80℃至负20℃
    标签:三肽   
  • An inhibitor of dipeptidyl aminopeptidase IV.

    Peptide H-IPI-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-IPI-OH include the following: A proteomics approach to study in vivo protein Nalpha-modifications X Zhang , J Ye, P Hojrup - Journal of Proteomics, 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1874391909002589 Identification and characterization of dipeptidyl peptidase-IV inhibitory peptides from oat proteins W Wang, X Liu, Y Li, H You, Z Yu, L Wang, X Liu - Foods, 2022 - mdpi.comhttps://www.mdpi.com/2304-8158/11/10/1406 Solvent Effects on the 310-/alpha-Helix Equilibrium in Short Amphipathic Peptides Rich in alpha,alpha-Disubstituted Amino Acids TS Yokum, TJ Gauthier, RP Hammer - Journal of the , 1997 - ACS Publicationshttps://pubs.acs.org/doi/full/10.1021/ja962875c Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in beta-lactoglobulin ST Silveira, D MartacaÂ\xadnez-Maqueda, I Recio - Food chemistry, 2013 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814613003683 Dipeptidyl peptidase IV inhibitory peptides from Chlorella vulgaris: in silico gastrointestinal hydrolysis and molecular mechanism Q Zhu, X Chen, J Wu, Y Zhou, Y Qian, M Fang - Food Research and , 2017 - Springerhttps://link.springer.com/article/10.1007/s00217-017-2879-1 Collagen derived Gly-Pro-type DPP-IV inhibitory peptides: Structure-activity relationship, inhibition kinetics and inhibition mechanism Q Xu, L Zheng, M Huang , M Zhao - Food Chemistry, 2024 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814624000189 IV (DPP-IV) inhibitory peptides derived from tilapia (Oreochromis niloticus) skin gelatin by an integrated approach of multivariate analysis and Gly-Pro-based peptide Q Xu, L Zheng, M Huang , M Zhao - Food Chemistry, 2022 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814622017836 The first structure in a family of peptidase inhibitors reveals an unusual Ig-like fold v2; ref status: indexed NDR Finn - 2013 - researchgate.nethttps://www.researchgate.net/profile/Neil-Rawlings-2/publication/260272656_The_first_structure_in_a_family_of_peptidase_inhibitors_reveals_an_unusual_Ig-like_fold/links/02e7e536cdc2545bf8000000/The-first-structure-in-a-family-of-peptidase-inhibitors-reveals-an-unusual-Ig-like-fold.pdf Relating electrospray ionization response to nonpolar character of small peptides NB Cech , CG Enke - Analytical Chemistry, 2000 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac9914869 Purification and characterization of multifunctional peptides with in situ insulinotropic and antioxidative activity from a blue whiting (Micromesistius poutassou) protein N Shekoohi, P Harnedy-Rothwell, S Sharkey - Journal of Functional , 2024 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1756464624001750 Rapid Screening of Novel Dipeptidyl Peptidase-4 Inhibitory Peptides from Pea (Pisum sativum L.) Protein Using Peptidomics and Molecular Docking M Zhang, L Zhu, G Wu, T Liu, X Qi - Journal of Agricultural , 2022 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jafc.2c03949 Ion-pair mediated transport of small model peptides in liquid phase micro extraction under acidic conditions JLE Reubsaet , JV Paulsen - Journal of separation science, 2005 - Wiley Online Libraryhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jssc.200401779 Investigation into the bioavailability of milk protein-derived peptides with dipeptidyl-peptidase IV inhibitory activity using Caco-2 cell monolayers IME Lacroix, XM Chen , DD Kitts , ECY Li-Chan - Food & Function, 2017 - pubs.rsc.orghttps://pubs.rsc.org/en/content/articlehtml/2017/fo/c6fo01411a Comparison of the susceptibility of porcine and human dipeptidyl-peptidase IV to inhibition by protein-derived peptides IME Lacroix, ECY Li-Chan - Peptides, 2015 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978115000741 Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins IME Lacroix, ECY Li-Chan - Peptides, 2014 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0196978114000059 Identification and quantification of DPP-IV-inhibitory peptides from hydrolyzed-rapeseed-protein-derived napin with analysis of the interactions between key residues F Xu, Y Yao, X Xu, M Wang, M Pan, S Ji - Journal of agricultural , 2019 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jafc.9b01069 Molecular Mechanistic Insights into Dipeptidyl Peptidase-IV Inhibitory Peptides to Decipher the Structural Basis of Activity C Wang, L Zheng, CC Udenigwe , L Lin - Journal of Agricultural , 2024 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/acs.jafc.3c08791 In silico study to predict potential precursors of human dipeptidyl peptidase-IV inhibitors from hazelnut C Li, R Qi, J Yuan, L Han , S Wang, W Li - Journal of Biomolecular , 2022 - Taylor & Francishttps://www.tandfonline.com/doi/abs/10.1080/07391102.2021.1961868 Strategic preparations of DPP-IV inhibitory peptides from Val-Pro-Xaa and Ile-Pro-Xaa peptide mixtures C Guan , S Iwatani, X Xing, N Yamamoto - International Journal of Peptide , 2021 - Springerhttps://link.springer.com/article/10.1007/s10989-020-10122-7 Evidence for the extent of insertion of the active site loop of intact. alpha. 1 proteinase inhibitor in. beta.-sheet A AJ Schulze, PW Frohnert, RA Engh, R Huber - Biochemistry, 1992 - ACS Publicationshttps://pubs.acs.org/doi/pdf/10.1021/bi00148a017 Identification of novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides in camel milk protein hydrolysates AB Nongonierma , S Paolella, P Mudgil , S Maqsood - Food Chemistry, 2018 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0308814617316692 DPP-4 Cleaves alpha/beta-Peptide Bonds: Substrate Specificity and Half-Lives A TuraliÃ\x84â\x80¡ , J Ã\x84Â\x90eÃ\x84â\x80\x98ibegoviÃ\x84â\x80¡ , Z Hegedus - Chembiochem, 2020 - Wiley Online Libraryhttps://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.202000050 Bioinformatics Analysis of IPIs in Five Northern Medicinal Plants A Hao, H Qi, H Guo, J Wei - Agricultural Science & Technology, 2016 - search.proquest.comhttps://search.proquest.com/openview/554f0f04d23171883a096b897cc2b297/1?pq-origsite=gscholar&cbl=1596357

  • DOI名称
    10.1016/j.foodchem.2012.02.183Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran下载
    10.1039/c4fo00983eIn vitro bioactive properties of intact and enzymatically hydrolysed whey protein: targeting the enteroinsular axis下载
    10.1042/BJ20021643Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII下载
    10.2337/diacare.26.3.837Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes下载
    10.1128/AAC.49.3.1087-1092.2005Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium下载
    10.1111/j.1742-4658.2005.04631.xThe structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity下载
    10.1016/j.neuint.2006.05.006The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats下载
    10.1021/jm0606490Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach下载
    10.1089/scd.2007.9997Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells下载
    10.1016/j.peptides.2007.07.012Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats下载
    10.33549/physiolres.931231Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines下载
    10.1152/ajpendo.90233.2008Incretin and islet hormonal responses to fat and protein ingestion in healthy men下载
    10.1007/s11064-008-9853-zThe effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats下载
    10.1016/j.exphem.2009.03.005Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A下载
    10.1038/oby.2009.378Neutral aminopeptidase and dipeptidyl peptidase IV activities in plasma of monosodium glutamate obese and food-deprived rats下载
    10.1210/jc.2011-0266Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans下载
    10.1016/j.biocel.2012.01.011Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity下载
    10.1016/j.molmet.2013.11.010Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency下载
    10.1210/jc.2014-3865Incretin effect after oral amino acid ingestion in humans下载
    10.1186/s13098-015-0075-7Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice下载
    10.7164/antibiotics.37.422Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria下载
    10.1016/s0014-5793(98)00515-8Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens下载
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