专肽生物_定制多肽合成服务_多肽合成定制服务_多肽合成厂家_多肽合成公司

α-Melanocyte-Stimulating Hormone (MSH), amide 是一种内源性神经肽，具有抗炎解热作用。α-MSH 是前阿黑皮素原翻译后的衍生物，是黑皮质素受体 4 (MC4R) 内源性的激动剂。

α-Melanocyte-Stimulating Hormone (MSH), amide is an endogenous neuropeptide, with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC), acts as an endogenous melanocortin receptor 4 (MC4R) agonist.

α-MSH，酰胺（C77H109N21O19S1），序列为Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2，分子量为1664.9。促黑素细胞激素，统称为MS或intermedins，是一类由垂体中叶细胞产生的多肽激素。MSH的增加导致人变黑。怀孕期间促黑素增加，伴随着雌激素的增加，引起孕妇色素沉着增多。库欣综合征是由于过量促肾上腺皮质激素（ACTH）导致色素沉着过度，例如腋窝黑棘皮症。大多数患有原发性阿狄森氏症的患者皮肤变黑（色素沉着过度），包括不暴露在太阳的部位，特征是皮肤皱折（例如手中）、乳头及脸颊（颊粘膜）的内部，旧疤痕可能会变暗。这是因为促黑素（MSH）和促肾上腺皮质激素（ACTH）具有相同的前体分子阿黑皮素原（POMC）。

促黑素是黑皮质素的一员，包括促肾上腺皮质激素、α-促黑素细胞激素（α-MSH）、（β-MSH）和（γ-MSH），这几个多肽是由前体肽阿黑皮素原（POMC）裂解的产物。α-MSH是色素沉着中最重要的黑皮质素。

α-MSH是一种与黑素皮质素1受体结合的肽。α-MSH是一种肽激素和神经递质，参与调节多种生理过程，包括食欲、性欲、免疫反应和皮肤色素沉着。除了作为天然激素的作用外，它还被研究作为治疗肥胖和其他疾病的潜在药物。该产品也可用作蛋白质印迹或免疫组织化学的抗体探针。

Alpha-MSH is a peptide that binds to the Melanocortin 1 receptor. Alpha-MSH is a peptide hormone and neurotransmitter that is involved in the regulation of numerous physiological processes, including appetite, sexual desire, immune response, and skin pigmentation. In addition to its role as a natural hormone, it has been studied as a potential drug for the treatment of obesity and other diseases. The product can also be used as an antibody probe for Western blotting or immunohistochemistry.

一种肽，能刺激两栖动物皮肤变黑，并可用于控制哺乳动物的学习、进食和动机。

Peptide that stimulates skin darkening in amphibians and can be used for controlling learning, feeding and motivating in mammals.

Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9. : https://pubmed.ncbi.nlm.nih.gov/21282427/
M S Kim, et al. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82. : https://pubmed.ncbi.nlm.nih.gov/10868932/