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Gap 26 TFA 是一种连接蛋白 (connexin) 模拟肽，由连接蛋白 connexin 43 (gap junction 阻滞剂)第一个胞外环的第 63-75 残基组成，包含SHVR氨基酸基序。
Gap 26 TFA is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif.

背景
Gap26 (Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg)是一种连接蛋白模拟肽，对应于connexin 43的63-75 aa，是间隙连接的阻断肽。

连接蛋白或间隙连接是一个结构相关的转膜蛋白家族。间隙连接包含允许离子和小分子穿过相邻细胞的通道。钙和磷酸肌醇是可以穿过间隙连接通道的第二信使[1]。据报道，gap26可以衰减兔动脉平滑肌的节律收缩活动，IC50值为28.4 mM。Gap26也可以阻断IP3诱导的ATP和Ca2+穿过连接蛋白半通道，即六聚通道，与相邻细胞对接从而形成间隙连接的管道[2]。

参考文献：

1. Boitano, S. and H. Evans Am. J. Physiol. Lung Cell Mol. Physiol. 279, L623 (2000).

2. T. Desplantez, V. Verma, L. Leybaert, W.H. Evans, R. Weingart, Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels, Pharmacological Research, Volume 65, Issue 5, May 2012, Pages 546-552.

Peptide H-VCYDKSFPISHVR-OH is a Research Peptide with significant interest within the field academic and medical research. Recent citations using H-VCYDKSFPISHVR-OH include the following: Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins V Verma , MB Hallett , L Leybaert , PE Martin - European Journal of , 2009 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S0171933508001192 Gap junctions modulate interkinetic nuclear movement in retinal progenitor cells RA Pearson , NL Luneborg, DL Becker - Journal of , 2005 - Soc Neurosciencehttps://www.jneurosci.org/content/25/46/10803.short Connexin43 modulates neutrophil recruitment to the lung MZR Sarieddine, KEL Scheckenbach - Journal of cellular , 2009 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1582-4934.2008.00654.x Enhanced Glutathione Efflux from Astrocytes in Culture by Low Extracellular Ca2+ and Curcumin MH Stridh, F Correa, C Nodin, SG Weber - Neurochemical , 2010 - Springerhttps://link.springer.com/article/10.1007/s11064-010-0179-2 Vascular smooth muscle modulates endothelial control of vasoreactivity via reactive oxygen species production through myoendothelial communications M Billaud , R Marthan, JP Savineau, C Guibert - PloS one, 2009 - journals.plos.orghttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006432 Connexin 43 mediates spread of Ca2+ -dependent proinflammatory responses in lung capillaries K Parthasarathi, H Ichimura, E Monma - The Journal of , 2006 - Am Soc Clin Investighttps://www.jci.org/articles/view/26605 Harnessing Radical Chemistry for the Facile Identification of Post Translational Modification Sites in Proteins by Photodissociation Mass Spectrometry J Diedrich - 2011 - escholarship.orghttps://escholarship.org/uc/item/5z62d38w Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury G Hawat, M Benderdour, G Rousseau - Pflugers Archiv-European , 2010 - Springerhttps://link.springer.com/article/10.1007/s00424-010-0849-6 Evidence for the involvement of myoendothelial gap junctions in EDHF-mediated relaxation in the rat middle cerebral artery EM Sokoya, AR Burns , CT Setiawan - American Journal , 2006 - journals.physiology.orghttps://journals.physiology.org/doi/abs/10.1152/ajpheart.01047.2005 Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro CS Wright , MAM Van Steensel - Wound repair and , 2009 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-475X.2009.00471.x Radical conversion and migration in electron capture dissociation BN Moore , T Ly , RR Julian - Journal of the American Chemical , 2011 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ja1096804 Gas Phase Radical Migration in Peptides and Proteins BN Moore - 2013 - escholarship.orghttps://escholarship.org/uc/item/83s0b5mg Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide A Garry, DH Edwards, IF Fallis - Cardiovascular , 2009 - academic.oup.comhttps://academic.oup.com/cardiovascres/article-abstract/84/2/218/325173 Direct elucidation of disulfide bond partners using ultraviolet photodissociation mass spectrometry A Agarwal, JK Diedrich, RR Julian - Analytical chemistry, 2011 - ACS Publicationshttps://pubs.acs.org/doi/abs/10.1021/ac201650v

13-mer connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif.